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【资讯翻译】Flu Vaccine May Not Protect Obese People, Study Finds

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发表于 2016-8-11 09:37:23 | 显示全部楼层 |阅读模式
Flu Vaccine May Not Protect Obese People, Study Finds

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Your Weight Could Make The Flu Shot Less Effective, WHO Reveals

A new mouse study is raising concern that the flu vaccine may not protect people that are obese.

The findings come amid ongoing concerns about flu pandemics launched by avian flu viruses and the global rise of obesity. The World Health Organization estimates that 10 percent of adults worldwide and 42 million children under the age of 5 now qualify as obese. Obesity leaves individuals at increased risk for flu-related complications, including hospitalization and death.

In this study, Researchers at St. Jude’s Research Hospital in Memphis, Tenn., used used vaccines prepared from killed viruses that are the basis of flu shots. The vaccines targeted an influenza A H1N1 seasonal flu strain as well as A(H7N9), a virus considered to have the potential to trigger a human pandemic.

Researchers looked at the immune response to vaccination in lean and obese mice, including how vaccine dose and the effect of different additives, called adjuvants, impacted that response. Both methods have been used to improve vaccine effectiveness in older adults and other high-risk groups.

While adjuvants improved the immune response to vaccinations in both lean and obese mice, the overall immune response was reduced in the obese animals compared to their lean counterparts. Following vaccination, the obese mice had lower antibody levels, including lower levels of neutralizing antibodies, and higher levels of the virus. In addition, lean mice receiving vaccines with adjuvants were protected from severe flu infections. Obese mice were not.

Researchers looked at the immune response to vaccination in lean and obese mice, including how vaccine dose and the effect of different additives, called adjuvants, impacted that response. Both methods have been used to improve vaccine effectiveness in older adults and other high-risk groups.

While adjuvants improved the immune response to vaccinations in both lean and obese mice, the overall immune response was reduced in the obese animals compared to their lean counterparts. Following vaccination, the obese mice had lower antibody levels, including lower levels of neutralizing antibodies, and higher levels of the virus. In addition, lean mice receiving vaccines with adjuvants were protected from severe flu infections. Obese mice were not.

A four-fold increase in the dose of A(H7N9) vaccine bolstered the immune response in both lean and obese mice, but failed to protect the heavier animals from flu-related deaths. Protective antibodies from lean mice also failed to protect obese mice from flu infections.

These findings suggest that obese individuals might be at risk for flu infections even if their blood antibodies reach what have been considered protective levels, say the researchers of the study, which appears in the journal mBio.
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http://www.medicalnewsservice.com/flu-vaccine-may-not-protect-obese-people-study-finds/


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发表于 2016-8-11 10:06:43 | 显示全部楼层
这篇我领了

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发表于 2016-8-11 14:15:29 | 显示全部楼层
研究表明流感疫苗不会保护肥胖人群


WHO最近指出你的体重水平可能会影响到流感疫苗的接种效果。

一项最新的小鼠研究指出流感疫苗可能对肥胖人群无保护效果。

禽流感病毒导致的流感爆发以及世界范围内的肥胖症的上升催生了这项研究。世界卫生组织估计世界10%的成人以及在5岁以下的4200万的儿童体重超标。肥胖症导致了流感相关并发症的风险增高,包括入院以及死亡。

在这项研究中,来自圣裘德研究医院的研究者使用了来自基于灭活病毒制备的流感注射疫苗。这种疫苗主要对H1N1以及H7N9流感病毒感染起保护作用,H1N1以及H7N9病毒可导致流感病毒在人群中的暴发流行。

研究者观察了瘦小鼠和肥胖小鼠在接种流感疫苗后的免疫反应,包括流感疫苗的剂量以及不同佐剂对免疫反应的影响。这些方法已被用到提高流感疫苗在老年人以及其他高危人群的免疫效果。

实验结果显示佐剂可以同时提高瘦小鼠和肥胖小鼠的疫苗免疫反应,但是在肥胖小鼠群体中,疫苗的总体免疫反应水平较瘦小鼠显著降低。接种免疫后,肥胖小鼠抗体水平较低包括较低的中和抗体水平同时肥胖小鼠的病毒载量较高。另外,瘦小鼠接种佐剂疫苗后可以预防较强流感病毒的感染,但是肥胖小鼠却不能.。

如果增加四倍剂量的H7N9疫苗可以在瘦小鼠和肥胖小鼠中均增强免疫反应,但是不能够降低肥胖小鼠的流感相关致死率。来自于瘦小鼠的保护性抗体同样不能够保护肥胖小鼠免于流感病毒感染。

这项研究发表在mBio杂志上,文章的作者说:”尽管接种过流感疫苗的肥胖者血液中的抗体达到保护性水平,但是肥胖的个体仍可能处在被流感病毒感染的风险当中。”

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 楼主| 发表于 2016-8-11 16:43:36 | 显示全部楼层
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