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【资讯翻译】Respiratory viruses in young South African children with ac...

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发表于 2016-6-20 13:44:03 | 显示全部楼层 |阅读模式
Respiratory viruses in young South African children with acute lower respiratory infections and interactions with HIV.
BACKGROUND:
Human rhinovirus (RV) is the most common respiratory virus and has been associated with frequent and severe acute lower respiratory infections (ALRI). The prevalence of RV species among HIV-infected children in South Africa is unknown.

OBJECTIVES:
To describe the prevalence of respiratory viruses, including RV species, associated with HIV status and other clinical symptoms in children less than two years of age with and without ALRI in Pretoria, South Africa.

STUDY DESIGN:
Nasopharyngeal aspirates were collected from 105 hospitalized ALRI cases and 53 non-ALRI controls less than two years of age. HIV status was determined. Common respiratory viruses were identified by PCR, and RV species and genotypes were identified by semi-nested PCR, sequencing and phylogenetic tree analyses.

RESULTS:
Respiratory viruses were more common among ALRI cases than controls (83.8% vs. 69.2%; p=0.041). RV was the most commonly identified virus in cases with pneumonia (45.6%) or bronchiolitis (52.1%), regardless of HIV status, as well as in controls (39.6%). RV-A was identified in 26.7% of cases and 15.1% of controls while RV-C was identified in 21.0% of cases and 18.9% of controls. HIV-infected children were more likely to be diagnosed with pneumonia than bronchiolitis (p<0.01). RSV was not identified in any HIV-infected cases (n=15) compared with 30.6% of HIV-uninfected cases (n=85, p=0.013), and was identified more frequently in bronchiolitis than in pneumonia cases (43.8% vs. 12.3%; p<0.01).

CONCLUSIONS:
RV-A and RV-C are endemic in South African children and HIV infection may be protective against RSV and bronchiolitis.


http://www.ncbi.nlm.nih.gov/pubmed/27317881


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发表于 2016-6-20 15:41:15 | 显示全部楼层
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发表于 2016-6-21 18:13:47 | 显示全部楼层
患有急性下呼吸道感染的南非幼儿感染的呼吸道病毒以及其与HIV的相互关系

背景:人鼻病毒(RV)是最常见的呼吸道病毒,而且与频繁且严重急性下呼吸道感染(ALRI)相关。RV物种在艾滋病毒感染的南非儿童中的患病率是未知的。

目的:
本研究的目的在于介绍在南非比勒陀利亚的患有或未患有ALRI的两岁以下儿童中,与艾滋病病毒感染状况和其他临床症状相关的包括RV物种在内的呼吸道病毒的患病率。

研究设计:
从105个住院治疗的两岁以下的ALRI病例和53个两岁以下的非ALRI对照中提取鼻咽分泌物。确定其艾滋病病毒感染状态。通过PCR对常见呼吸道病毒进行识别,通过半巢式PCR、测序和进化树分析法对RV物种和基因型进行识别。

结果:
与对照组相比,呼吸道病毒在ALRI病例中更为普遍(69.2%对83.8%,P = 0.041)。无论HIV感染状况如何,在肺炎(45.6%)或细支气管炎(52.1%)的病例中,RV是最普遍被识别的病毒,在对照组中亦然(39.6%)。RV-A在26.7%的病例和15.1%的对照组中被识别,而RV-C在21.0%的病例和18.9%的对照组中被识别。与细支气管炎相比,HIV感染的儿童更容易被诊断为肺炎(p <0.01)。在所有HIV感染病例中,RVS均未被识别(n = 15),与之相对的是在30.6%的HIV未感染病例中识别出RVS(n = 85,p = 0.013),此外,与在肺炎病例中相比,在细支气管炎中更频繁地检测出RSV(12.3%对43.8%,p <0.01)。

结论:
RV-A和RV-C在南非儿童中流行,此外,HIV感染可能能够保护其免遭RSV及细支气管炎的侵害。

http://www.ncbi.nlm.nih.gov/pubmed/27317881

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 楼主| 发表于 2016-6-22 08:58:08 | 显示全部楼层
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