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【资讯翻译】Impact of post-chemoradiotherapy superselective/selective n...

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发表于 2016-6-20 13:41:24 | 显示全部楼层 |阅读模式
Impact of post-chemoradiotherapy superselective/selective neck dissection on patient reported quality of life.

OBJECTIVES:
To describe patient-reported quality of life (QoL) for patients with HPV/p16-positive oropharyngeal squamous cell carcinoma undergoing post-chemoradiation (CRT) superselective or selective neck dissection (ND) as part of a prospective de-intensification study.

MATERIALS AND METHODS:
Patients received 60Gy IMRT with concurrent weekly cisplatin (30mg/m(2)), followed by preplanned neck dissection of only originally involved nodal levels. QoL measures were assessed using the EORTC QLQ-C30 (general), EORTC H&N-35 (head and neck specific), EAT-10 (swallowing), and NDII (Neck Dissection Impairment Index) questionnaires. Early and late post-ND time points were compared to baseline and post-CRT/pre-ND time points.

RESULTS:
37 patients underwent post-CRT superselective or selective ND. Median # of levels and nodes dissected were 2 and 12, respectively. EORTC QLQ-C30, H&N-35, and EAT-10 QoL scores worsened after CRT but continued to improve thereafter despite post-CRT ND. NDII score worsened initially after ND at the early post-ND time point (p=0.023) but had recovered by the late post-ND time point (p=0.672). Initial decrease in NDII was greater with ⩾12 nodes dissected (p=0.007) and was correlated with the total number of nodes dissected (Spearman p=0.027).

CONCLUSION:
Use of post-CRT superselective and selective ND did not prevent recovery of most QoL metrics to near baseline. There was early but not late decrement in neck dissection specific QoL (NDII), more pronounced with more nodes dissected.

http://www.ncbi.nlm.nih.gov/pubmed/27311398


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发表于 2016-6-20 13:47:28 | 显示全部楼层
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发表于 2016-6-20 15:51:10 | 显示全部楼层
化放疗后超选择或选择性颈淋巴结清扫术对患者报道的生活质量的影响

       目的:对经历放化疗(CRT)后超选择或选择性颈淋巴清扫术(ND)的HPV/p16阳性的口咽部鳞状细胞癌患者报道的生活质量(QoL)进行描述,并作为一个前瞻性的去强化研究的一部分。
       材料与方法:患者接受60Gy调强放射治疗(IMRT),同步每周顺铂(30mg/m(2)),接着接受原本只涉及淋巴结水平的预定的颈淋巴清扫术。生活质量的测定由EORTC QLQ-C30评估(常规),EORTC H&N-35(头颈针对性),eat-10(吞咽),与NDII(颈淋巴结清扫术损伤指数)调查问卷等进行评价。ND后早期和晚期的时间点与基线和CRT 后/前的时间点进行比较。
       结果:37例患者进行CRT后超选择或选择性ND。清扫水平和淋巴结数中位数分别为2和12。CRT后EORTC QLQ-C30,H&N-35,和EAT-10 QOL评分恶化,但是不管是否尽心ND,其分值都得到了改善。NDII评分在接受ND后早期时间点恶化Nd(P = 0.023),但在ND后晚期时间点得到恢复(P = 0.672)。在清扫节点⩾12的患者中,NDII评分的厨师减少值要更大(P = 0.007),并与清扫的淋巴结总数相关(Spearman P = 0.027)。
       结论:CRT后超选择和选择性ND并不会阻止大多数生活质量指标恢复到接近基线。有颈淋巴清扫术特异性QoL降低发生在术后早期,而在术后晚期并不会,同时清扫的淋巴结数目越多,这种降低也显著。

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 楼主| 发表于 2016-6-21 08:57:38 | 显示全部楼层
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