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【资讯翻译】Blood test can predict risk of developing tuberculosis

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发表于 2016-3-24 08:52:21 | 显示全部楼层 |阅读模式
Blood test can predict risk of developing tuberculosis

One-third of the world's population is thought to be infected with Mycobacterium tuberculosis (Mtb), the bacterium that causes tuberculosis (TB), but just a small fraction ever develops symptomatic illness. Now, an international team of researchers has identified biological markers in the blood of latently infected people that may give doctors a tool they have long sought: a way to predict who is at high risk of developing active TB. If validated through additional clinical trials, a test based on these blood biomarkers would allow doctors to target therapies to at-risk people, thus preventing them from getting sick.

The decade-long research effort was led by investigators from the South African Tuberculosis Vaccine Initiative at the University of Cape Town, and the Center for Infectious Disease Research, Seattle. It was funded in part by the National Institutes of Health.

The biomarkers were identified in two stages. First, researchers collected blood samples for two years from more than 6,000 Mtb-infected but otherwise healthy adolescent volunteers in South Africa. Analysis of the samples revealed patterns of gene expression that differed between volunteers who eventually developed TB and those who remained healthy. This risk "signature," confined to a set of 16 genes, could be detected in a blood sample as early as 18 months before the infected person developed active TB.

Next, the team confirmed the genetic risk signature's predictive ability in a study of more than 4,500 volunteers in South Africa and The Gambia. Volunteers in this study were healthy but lived with people who had recently been diagnosed with active TB. The second study group was more varied in age, health status, ethnicity and exposure to locally common strains of Mtb than volunteers in the first study. Despite the differences, the same risk signature found in the first study was detected in the people who eventually developed active TB during the second trial.

信源地址:http://medicalxpress.com/news/2016-03-blood-tuberculosis.html

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发表于 2016-3-24 10:49:53 | 显示全部楼层
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发表于 2016-3-24 16:17:19 | 显示全部楼层
           血液检测可预测患肺结核的风险性
    世界上三分之一的人口被认为感染了结核分枝杆菌(MTB),细菌引起结核病(TB),但只是一小部分发展成有症状的疾病。现在,国际研究小组的研究人员已从潜伏感染的人提取血液生物标志物,这个标志物给医生提供了向往已久的工具:一种来预测患高风险活性结核病的方式。如果通过额外的临床试验的验证,医生基于这些血液生物标记测试,将对高危人群进行靶向治疗,从而防止生病状况。
    美国开普顿大学的南非结核疫苗倡议和西雅图传染病研究中心的研究领导了这十年的研究工作,该项工作由美国国家卫生研究所资助。
    生物标志物将进行2个阶段的鉴定。首先,研究人员在南非两年期间从6000多分枝杆菌感染但身体健康的青少年志愿者身上采集血样。通过对样本的分析显示,患有结核病的和保持健康的不同志愿者基因表达模式大不相同。这种风险的“标志”仅局限于一组16个基因,受感染患者转变为的活性结核病的18个月内可以在其的血液样本中检测到。
    然后,研究小组在南非和冈比亚对4500多名志愿者的遗传风险‘标志’的预测能力研究中得到证实。这项研究中的志愿者是健康的,但最近与诊断为活动性结核病的人一起生活。第二次研究相比第一次研究在志愿者年龄、健康状况、种族和暴露于局部结核常见菌株的情况相差很大。尽管存在差异,在第二次研究过程中,最终发现活性肺结核的人群中发现了相同的风险特征。

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 楼主| 发表于 2016-3-25 10:39:31 | 显示全部楼层
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