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【资讯翻译】Evaluation of serum granulysin as a potential biomarker for...

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发表于 2016-1-12 14:33:41 | 显示全部楼层 |阅读模式
Evaluation of serum granulysin as a potential biomarker for nasopharyngeal carcinoma


Background
Granulysin (GNLY) is excreted from cytotoxic T lymphocytes and natural killer cells, and plays an important role in antitumor immunity. However, few studies have estimated serum GNLY concentrations in patients with nasopharyngeal carcinoma (NPC). We evaluated GNLY as a potential biomarker for NPC.
Methods
Serum GNLY concentrations were measured in blood samples taken from 98 NPC patients, 56 nasopharyngitis (NPT) patients, and 99 healthy subjects. The clinical relevance of GNLY in NPC was also investigated. We also assessed the association between serum GNLY and serum immunoglobulin A antibodies against the Epstein–Barr virus (EBV) viral capsid antigen (VCA-IgA) and EBV DNA.
Results
Serum GNLY levels were significantly lower in NPC patients and significantly higher in nasopharyngitis patients compared to healthy controls. Thus, serum GNLY performs well as a biomarker for distinguishing between NPC and NPT. The serum GNLY concentration is elevated with corresponding increases in clinical stage and shows a significant correlation with VCA-IgA and EBV DNA concentration.
Conclusions
Serum GNLY is closely associated with the clinical characteristics of NPC and may be a potential biomarker for NPC.

信源地址:http://www.sciencedirect.com/science/article/pii/S0009898115301042

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发表于 2016-1-12 19:05:55 | 显示全部楼层
这篇我领了~~

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发表于 2016-1-13 21:21:04 | 显示全部楼层
血清粒溶素评估可作为鼻咽癌的潜在分子标志物

背景
粒溶素是由细胞杀伤性T细胞和自然杀伤细胞分泌的,其在抗肿瘤免疫中发挥着重要的作用。然而,却很少有研究来评估血清粒溶素在鼻咽癌病人体内的浓度。我们评估了粒溶素作为鼻咽癌的潜在分子标识。

方法
检测98例鼻咽癌患者、56例鼻咽炎患者以及99例健康人群的血清粒溶素。粒溶素在鼻咽癌患者中的临床相关性同样被研究。我们同时评估了血清粒溶素以及针对EB病毒病毒衣壳免疫球蛋白A以及EB病毒DNA的关联性。

结果
血清粒溶素在鼻咽癌患者体内的水平显著低于正常人,同时血清粒溶素在鼻咽炎患者体内的显著高于正常人。因此,血清粒溶素可以很好的评估和区分鼻咽癌和鼻咽炎。血清粒溶素浓度随着临床不同时期逐渐提升并且针对EB病毒病毒衣壳免疫球蛋白A以及EB病毒DNA之间具有显著的相关性。

结论
血清粒溶素与鼻咽癌的临床特征具有显著的相关性并可作为鼻咽癌的潜在分子标识物。

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 楼主| 发表于 2016-1-15 10:50:54 | 显示全部楼层
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