欢迎来到艾兰博曼,请 登录 | 立即注册
查看: 1358|回复: 3

【资讯翻译】The Canadian experience on pediatric liver disease: Early d...

[复制链接]

10

听众

10

收听

1954

积分

管理员

Rank: 9Rank: 9Rank: 9

积分
1954
发表于 2015-10-22 08:30:54 | 显示全部楼层 |阅读模式
The Canadian experience on pediatric liver disease: Early diagnosis is critical

A first of its kind nationwide study on pediatric Autoimmune Hepatitis (AIH), a progressive inflammatory liver disease, was released today in the esteemed journal, Pediatrics.

Led from the Children's Hospital of Eastern Ontario (CHEO) including 13 pediatric academic centers across Canada, the research team conducted a retrospective chart review spanning 10 years to unveil: the incidence of AIH; how patients present with the disease; variances in treatment across Canada; and patient outcomes.

"Before now, there was little data on incidence and prevalence of AIH in Canada and even the worldwide literature is scarce," said Dr. Carolina Jimenez, lead author, and director of Liver Services Gastroenterology, Hepatology and Clinical Nutrition at CHEO, and assistant professor at the University of Ottawa. "Liver disease is not just an adult problem. Our hope is to equip family physicians and specialists alike with evidence-based data so they can start investigations and refer patients earlier; this way kids get treated faster and will have better outcomes."

The team found 159 children under 18 years old with AIH, which represents 2.3 per million in Canada. Although not a common disease, its incidence is higher in the eastern provinces. Fatigue, jaundice, and abdominal pain were the most common presenting symptoms. The review also found that is takes a long time to diagnose AIH, during which time a child's symptoms can get worse.

"Our paper underscores the importance of recognizing and treating this disease early," said Dr. Fernando Alvarez, professor of Pediatrics, Sainte-Justine Hospital, University of Montreal. "We can do more for this population of very sick children if we aim to standardize care across Canada. Access to this type of information is a step in the right direction."

One quarter of children with AIH have a family history of autoimmune diseases. 20% of all children presented with cirrhosis from the onset, which reflects chronicity of the disease and the time it takes to confirm the diagnosis, but responded well to conventional therapy -- diminishing the need for a liver transplant.

The review also unveils new tests for diagnosing AIH, including a MRI and blood test. There are variances in the types and dosage of medicines used to treat AIH across Canada too.

信源地址:http://www.medicalnewstoday.com/releases/301274.php

0

听众

0

收听

387

积分

中级会员

Rank: 3Rank: 3

积分
387
发表于 2015-10-22 09:16:59 | 显示全部楼层
领了。。。。。。。。。。。

0

听众

0

收听

387

积分

中级会员

Rank: 3Rank: 3

积分
387
发表于 2015-10-22 11:03:48 | 显示全部楼层
加拿大在小儿肝病中的经验:早期诊断非常重要

      今天,权威性杂志《儿科学》发布了首例关于一种进展性炎症性肝病——小儿自身免疫性肝炎(AIH)的全国性研究。
      该研究由安大略东部儿童医院(CHEO)主持,包含了来自加拿大全国的13所儿科学术中心,研究团队花费10年时间绘制了回顾性图表来揭示以下几个问题:AIH的发生率;病人如何出现该疾病;加拿大不同地区治疗该疾病的差异;以及病人的预后。
      “在此之前,没有任何关于AIH在加拿大的发生率和流行的数据,甚至世界范围的文献报道也很少”,Carolina Jimenez博士说到。Carolina Jimenez博士是该文章的主要作者,CHEO胃肠病,肝病和临床营养协会肝病服务中心主任,渥太华大学助理教授。他说:“肝病不仅仅是成年人的问题。我们希望为家庭医生和专科医生等人提供循证数据以期望他们早点开始研究和提醒病人,如此做可以使得小孩子可以更快地获得治疗并有较好的预期”。 疲劳,黄疸,腹痛是AIH的典型症状。团队找到159位18岁以下的患有AIH的儿童,这个数据等同每百万加拿大人中有2.3人次。尽管AIH不是一种常见病,但是它在加拿大东部的发生率更高。该回顾性研究同时也发现,AIH的诊断需要很长时间,而在这么长的诊断过程中,小孩子的症状会变得跟恶劣。
      “我们的文章强调对该病的早期识别和治疗的重要性”,Fernando Alvarez博士(蒙特利尔大学,Sainte-Justine医院,儿科教授,)说:“如果我们致力于在加拿大进行AIH治疗的标准化,那么我们可以为这群病的很重的小孩作做多的事情。对于这类信息的获取正是沿着该方向迈进的正确的一步”。
      1/4的AIH小孩具有自身免疫疾病的家族史。20%的小孩在疾病开始期表现出肝硬化的症状,这表明该病具有慢性长期性和确诊的耗时性。但是传统治疗方案对该病的治疗效果的较好,即可以减少对肝移植的需求。
      这项回顾性研究同时揭示了AIH诊断的新方法,包括MRI和血液检测。
      同时,在加拿大存在着AIH治疗药物的类型和剂量的差异。

0

听众

0

收听

355

积分

版主

Rank: 7Rank: 7Rank: 7

积分
355
发表于 2015-10-22 16:47:18 | 显示全部楼层
收了
您需要登录后才可以回帖 登录 | 立即注册

本版积分规则

© 2013 艾兰博曼 All Rights Reserved.
( 浙ICP备07020270号-8 )
 
快速回复 返回顶部 返回列表