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【资讯翻译】Risk of venous and arterial thrombotic events in patients d...

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发表于 2015-1-9 10:46:29 | 显示全部楼层 |阅读模式
Risk of venous and arterial thrombotic events in patients diagnosed with superficial vein thrombosis: a nationwide cohort study


Recently, it has become apparent that superficial vein thrombosis (SVT) can have serious complications. However, the magnitude of the risk of subsequent deep venous and arterial thrombotic events remains unknown. We examined this in a nationwide population-based setting during a period when SVT was not treated routinely with anticoagulants. The Danish National Registry of Patients, covering all Danish hospitals, was used to identify 10 973 patients with a first-time diagnosis of SVT between 1980 and 2012. A comparison cohort of 515 067 subjects, matched by age, gender, and calendar year, was selected from the general Danish population. Outcomes were venous thromboembolism, acute myocardial infarction, ischemic stroke, and death. During median follow-up of 7 years, the incidence rate of venous thromboembolism was 18.0/1000 person-years (95% confidence interval [CI], 17.2-18.9). The highest risk occurred in the first 3 months (3.4%; 95% CI, 3.0-3.7). Compared with the general population, the hazard ratio was 71.4 (95% CI, 60.2-84.7) in this period, steadily decreasing to 5.1 (95% CI 4.6-5.5), 5 years after the SVT. The hazard ratios for acute myocardial infarction, stroke, and death were 1.2 (95% CI, 1.1-1.3), 1.3 (95% CI, 1.2-1.4), and 1.3 (95% CI, 1.2-1.3), respectively, with the highest risk also shortly after SVT. These data indicate the prognostic importance of SVT and may form the basis for clinical decision-making regarding anticoagulation.

信源地址:http://www.bloodjournal.org/content/125/2/229

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发表于 2015-1-9 17:23:43 | 显示全部楼层
领了。。。。。。。。。。。。。。。

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发表于 2015-1-12 10:58:15 | 显示全部楼层
                                                             一项对浅静脉血栓形成病人静脉和动脉血栓性事件的全国性群体研究
       最近,关于浅静脉血栓形成(SVT)可以带来严重的并发症这一事实越来越清晰。然而,其继发性的深层静脉和动脉血栓性事件的风险大小仍是未知的。我们设置了以全国人口为基础的群体研究,并测定了未接受抗凝血剂常规治疗的SVT病人中该风险的大小。从1980年至2012年覆盖所有丹麦医院的丹麦国家登记病人中,鉴定出了初次诊断出SVT症状的病例共10973人次。从丹麦普通人群中筛选出年龄,性别,历年相匹配共515 067个对象作为比较。以静脉血栓栓塞,急性心肌梗死,缺血性发作,和死亡为考察对象。在中位值为7年的随访中,静脉血栓栓塞发生率为1000人中18.0人次(95% CI, 17.2-18.9)。风险最高时期在随访的头3个月(3.4%; 95% CI, 3.0-3.7)。与普通人群比较,这个时期的风险率是71.4(95% CI, 60.2-84.7),伺候,在SVT诊断出来的5年内,这个数值稳定地降低至5.1(95% CI,4.6-5.5)。急性心肌梗死,中风,和死亡的风险率分别为1.2 (95% CI, 1.1-1.3), 1.3 (95% CI, 1.2-1.4), and 1.3 (95% CI, 1.2-1.3)。风险最高时期在SVT发现后的极短时间内。这些数据表明SVT具有重要的预测性,以及对关于抗凝血剂的临床决策形成基础。(pxb译)

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 楼主| 发表于 2015-1-13 13:47:11 | 显示全部楼层
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发表于 2015-1-26 16:17:22 | 显示全部楼层
hjj

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发表于 2015-3-30 10:55:28 | 显示全部楼层
非常强大!
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